In silico modeling of phenotypes and clinical outcomes using pharmcometric and system biology approaches has a great application in drug discovery, regulatory decision and rational drug treatment in patients. We are particually interested in the following two research fields: (1) predictive gene signature using gene network analysis, and (2) new algorithms to improve the successful rates of clinical outcome prediction. To facilitate us to deploy the developed models, we are also interested in developing user-friendly web-toolkits to deploy the developed computer models.